<p>High dose of vancomycin plus gentamicin incorporated acrylic bone cement decreased the elution of vancomycin</p>
نویسندگان
چکیده
منابع مشابه
Gentamicin elution profile of SmartSet GHV Gentamicin Bone Cement
Introduction There is no doubt that, since the invention of artificial joint replacement, many thousands of people have enjoyed freedom from disabling pain and immobility. However, this remarkable success story is marred by the incidence of local sepsis following surgery, which can lead to prosthesis loosening and the need for revision surgery. In fact, deep wound infections are the most seriou...
متن کاملIncreasing the elution of vancomycin from high-dose antibiotic-loaded bone cement: a novel preparation technique.
BACKGROUND Antibiotic bone cement is commonly used in staged revision arthroplasty as well as the treatment of open fractures. Multiple factors affect antibiotic elution from bone cement. This study was performed to investigate the effect of two variables, the quantity of liquid monomer and the timing of antibiotic addition, on the ultimate elution of antibiotic from bone cement. METHODS Vanc...
متن کاملCombination of modified mixing technique and low frequency ultrasound to control the elution profile of vancomycin-loaded acrylic bone cement.
OBJECTIVES The objective of this study was to determine if combining variations in mixing technique of antibiotic-impregnated polymethylmethacrylate (PMMA) cement with low frequency ultrasound (LFUS) improves antibiotic elution during the initial high phase (Phase I) and subsequent low phase (Phase II) while not diminishing mechanical strength. METHODS Three batches of vancomycin-loaded PMMA ...
متن کاملGentamicin in bone cement
OBJECTIVES The objective of this study is to determine an optimal antibiotic-loaded bone cement (ALBC) for infection prophylaxis in total joint arthroplasty (TJA). METHODS We evaluated the antibacterial effects of polymethylmethacrylate (PMMA) bone cements loaded with vancomycin, teicoplanin, ceftazidime, imipenem, piperacillin, gentamicin, and tobramycin against methicillin-sensitive Staphyl...
متن کاملElution and antibacterial activity of meropenem from implanted acrylic bone cement.
References 1 Nordmann P, Cuzon G, Naas T. The real threat of Klebsiella pneumoniae carbapenemase-producing bacteria. Lancet Infect Dis 2009; 9: 228–36. 2 Wolter DJ, Kurpiel PM, Woodford N et al. Phenotypic and enzymatic comparative analysis of the novel KPC variant KPC-5 and its evolutionary variants, KPC-2 and KPC-4. Antimicrob Agents Chemother 2009; 53: 557–62. 3 Endimiani A, Patel G, Hujer K...
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ژورنال
عنوان ژورنال: Infection and Drug Resistance
سال: 2019
ISSN: 1178-6973
DOI: 10.2147/idr.s203740